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In the same study, higher spermidine levels were associated with good water maze performances and decreased anxiety, whereas spermine had the opposite effect, suggesting differential roles for spermidine and spermine in behavioural outcome

Proc Natl Acad Sci USA (1987) 84:30048

Y.RamachandranA.DuanL.SchaichM

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Experimental studies have shown that inhibition of miR-34a in mice fed an HFD increases PPAR expression and AMPK activation, which promotes fatty acid -oxidation and reduces TG accumulation in the liver [300]