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NAC has stronger clinical evidence for liver support and is used in NHS hospitals for paracetamol overdose, whereas direct glutathione supplements have variable absorption and limited evidence for fatty liver disease

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Prez-Madrigal MM, Shaw JE, Arno MC, Hoyland JA, Richardson SM, Dove AP

Taken together, these experiments point to extracellular determinants for melanogenesis and support the conclusion that extracellular changes in gsh2 mutants lead to a redox environment incompatible with melanin formation