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However, inhibitors of autophagy, necroptosis and apoptosis only partially improved survival substantially, suggesting that ferroptosis is essential for DOX-induced cardiomyopathy and mortality in mice [91]

In cases where therapeutic benefits were observed in clinical trials, it often became apparent that these effects were unrelated to the compounds antioxidant activity

[PubMed 12536052] 3442

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Our results clearly demonstrated that HFD consumption was associated with hepatic activation of both JNK and caspase-3 (Fig