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Low levels of B12 can lead to: Fatigue Weakness Digestive issues Shortness of breath Numbness or tingling in the fingers and toes Difficulty walking / balance problems Cognitive impairment or memory loss A person can also have low levels of vitamin B without exhibiting any obvious symptoms

Coombes BK, et al

5 Prediabetes is a significant risk factor for DN, with the prevalence of DPN among prediabetes individuals ranging from 6 to 25%

These modifications are discussed in research literature for their effect on reducing binding affinity to insulin-like growth factor binding proteins, resulting in extended biological half-life in experimental models

Safety and Research Limitations Importantly, No adequate clinical evidence defines safe human exposure, maximum tolerated dose, reproductive toxicity, carcinogenicity, genotoxicity, cardiovascular risk, liver safety, kidney safety, endocrine effects, or drug interactions