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A study using a panel of cell lines of high-risk neuroblastoma, a cancer characterized by increased MAPK signaling, found drastic variations in sensitivity to serine/tyrosine/threonine kinase inhibitors between these cell lines (7)

However, validated medical treatments (UVB phototherapy, topical corticosteroids, calcineurin inhibitors, JAK inhibitors such as ruxolitinib) can enable partial or complete repigmentation in some patients

2014;40:10031021 Quinn CT, St Pierre TG

Besides CoQ and VK, which act as RTAs to inhibit ferroptosis, reduced forms of vitamin E, vitamin A, and tetrahydrobiopterin (BH4) are also included

Woolston et al