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FIGURE 6 4.1 Antioxidant therapy Antioxidants are direct strategy to neutralize ROS and reduce oxidative stress, and play an important role in the treatment of skin diseases

Catalase (CAT) is another first-line antioxidant enzyme that dismutates H 2 O 2 to H 2 O and O 2

However, neutrophilic inflammation is the dominant endotype in COPD patients [36] and the neutrophilic inflammatory pathway responds poorly to corticosteroids [37]