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Manganese and the brain

8.2 Blood and CSF biomarkers Once considered a mere waste product of metabolism, L-lactate is now acknowledged for its various physiological functions in the central nervous system, such as modulating neuronal activity and ensuring energy balance (140, 141)

Polyunsaturated fatty acids present in biological membranes are attacked by ROS resulting in an imbalance in the fluidity and integrity of membrane phospholipids [87]

10.1093/brain/awt023 119

These findings emphasize the necessity of examining both short-term and long-term exposures to fully elucidate the biochemical pathways and molecular mechanisms