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Transfection of GES-1 cells with miRNA-143, miRNA-152, and miRNA-181 mimics significantly decreased mature miRNA expression accompanied by xCT mRNA, and protein expression was significantly suppressed (Figures 4A,B)

Only Manganese superoxide dismutase (MnSOD), the main mitochondrial neutralizer of ROS, has been shown to be crucial for the survival of aerobic life (26)