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Mechanistically, G3BP1, an SG core protein, directly interacts with ferritin light chain in an IR/TMZ-induced G3BP1 methionine-333 oxidation-dependent manner

Carcinogenesis 28 (5), 10211031

& Myllyharju, J

Tsukimori K, Komatsu H, Fukushima K, Kaku T, Nakano H, Wake N

This combined approach addresses both the acute oxidative insult and the underlying metabolic capacity and resilience of auditory cells, offering a promising, multi-faceted therapeutic avenue for preventing noise-induced hearing loss and its frequent sequela, tinnitus, by safeguarding the energetic and redox homeostasis of the auditory system see in Figure 2 -