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Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-gamma pathway

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In wild-type and ob/ob mice, adiponectin heightens uncoupling protein 1 (UCP1, thermogenin) mRNA levels in BAT and encourages thermogenesis, without modifying food intake

Therefore, we challenged mice with hepatic-specific PGC-1 overexpression on a chow diet with a subtoxic dose of APAP and we found that PGC-1 overexpression renders the liver more sensitive to APAP damage, mainly due to intense oxidative stress, finally ending up with liver necrosis and mice death

10.1016/j.ijpharm.2018.07.068 [DOI] [PubMed] [Google Scholar] Piipponen M., Li D., Landn N