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The main objective of managing obesity is to enhance health, as achieving a sustained weight loss exceeding 10% of total body weight significantly improves various obesity-related conditions, including type 2 diabetes (T2D), hypertension, fatty liver disease, and obstructive sleep apnea, ultimately leading to a better quality of life (5)

J Hepatol 2017;66:825835

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However, it is important to note that flaws in the docking method do persist, as it employs rigid protein structures, which limit accurate predictions