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Furthermore, structural features of the calcium-dependent carbohydrate recognition domain with a relatively shallow surface pose a challenge to the rational design of selectin inhibitors

05B0131, Baltimore, MD 21224, USA e-mail: [email protected] This article was submitted to Oxidant Physiology, a section of the journal Frontiers in Physiology

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These recent experimental findings are biologically plausible, particularly as both oxidative stress and neuroinflammation are increasingly recognized as important contributors to the pathophysiology of ASD (151, 156, 160)