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For instance, Fer-1, similar to other hydrophobic drug candidates, is unsuitable for clinical development because of its limited capacity to traverse the blood-brain barrier (BBB) and its poor water solubility [216]

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Still, the strong influence of oxaliplatin was unexpected, considering the lack of impact in vitro (compare Supplementary Fig

As the largest organ of the human body, the skin serves not only as a barrier, defense, and sensory interface, but also as a key player in metabolic regulation