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10.3748/wjg.v23.i8.1375 115 ShinD.ChoE

Usually, the addition of methyl groups to histones causes them to close, rendering the DNA coiled around them inactive and, thus, silent

The bodys inflammatory response results in an increase of white blood cells which release chemical messengers called cytokines

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In the early 21st century, when no disease-modifying treatments for AD were available, diagnostic biomarkers with mechanistic specificity, such as CSF A 142 /tau ratios or amyloid PET imaging, began to serve a dual role as selection biomarkers in clinical trials