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Description

FASEB J off Publ Fed Am Soc Exp Biol 18:19171919

Alprazolam orally disintegrating tablets are contraindicated in patients treated with potent CYP3A4 inhibitors (e.g., ketoconazole and itraconazole), because these medications significantly impair the oxidative metabolism mediated by cytochrome P450 3A (CYP3A) and can increase alprazolam exposures [see Clinical Pharmacology (12.3), Warnings and Precautions (5.9), and Drug Interactions (7.4)]

Metabolic signaling

The role of the liver is to transform fat-soluble molecules into water-soluble molecules, preparing them for excretion by entering the bloodstream and being removed by the body