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Proceedings of ASH , abstract 1166 (2007)

Vitamin B12 Deficiency Symptoms Deficiency may result in various disturbances such as hematological, neurological, and psychiatric problems, observed as the following symptoms: Feeling tired/weak or confused Tingling or numbness in fingers and toes Constipation, balance issues Depression and cognitive issues A swollen, inflamed tongue Anemia Deficiency symptoms tend to manifest gradually over a few years, and it is recommended to check blood serum levels for early detection [7]

[5]Current Patent Assignee: INCYTE HOLDINGS - US2009/233903, 2009, A1 Location in patent: Page/Page column 54-55

Overlooking arthritis can lead to chronic stiffness

High levels of reactive oxygen species directly sensitize mast cells, altering their intracellular calcium levels and provoking them into inappropriate, constant degranulation