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Dysregulated mTORC1 and TFEB signaling exacerbate these autophagic defects, prompting research into the use of autophagy modulators as potential therapeutic strategies [144, 146]

Int J Cancer 79:517520 Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J (2004) Lifestyle related risk factors in the etiology of gastro-oesophageal reflux