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Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes

ADHD often shows up as: Difficulty sustaining attention Impulsive behaviour High activity levels Struggles with organisation and planning In ADHD, the brain has differences in regulating focus, behaviour and self-control

In particular, the intraperitoneal administration of K1K1 resulted in a strong neuroprotective activity on motor neurons in ALS animal models (Vallarola et al., 2020)

Hirayama, K., Endo, K., Kawamura, S