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Ethics declarations Ethics approval and consent to participate All animal studies were accredited by the Institutional Ethics Committee and followed the requirements for the care and use of laboratory animals of the Hangzhou Institute of Medicine (HIM) of the Chinese Academy of Sciences (AP2025-11-0636)

2017;5:Article 162

It has been considered that the bone-derived factors can act as a new gateway to regulate glycemia, the changes of osteokines expression and secretion have the directly or indirectly influences in the liver homeostasis

As estrogen deficiency-induced redox imbalance may contribute to renal deterioration