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In a phase I clinical trial (NCT00456157), patients treated with 0.1 mg and 0.3 mg doses of BMP-7 exhibited greater symptomatic improvement compared with those receiving placebo, and no ectopic bone formation or dose-limiting toxicity was observed among patients treated with BMP-7 [107]

Riboflavin (vitamin B2) is an essential B vitamin, and deficiencies may impair iron absorption, increase intestinal loss of iron, and impair iron utilization