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Despite the FDA recommendation of a 48-week treatment period for PPIs (2), nearly 7% of PPI users continue therapy for more than 3 years, surpassing the recommended FDA usage guidelines and increasing the propensity for adverse long-term effects (3, 4)

222 In addition, the overexpression of other components of the -secretase complex, including nicastrin, anterior pharynx-defective 1 (Aph-1), and presenilin enhancer 2 (Pen 2), also suppresses p53 expression in AD animal models

Nisin showed the highest expression of norepinephrine in the brain as compared to the control group and ciprofloxacin-treated group

Although many other metal ions, such as Zn 2+ , Cd 2+ , Pb 2+ , etc, could interact with a terminal carboxylic acid functional group of GSH, we find that such a molecular-gap device show an excellent specifity towards Hg 2+