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These fatty acids have been associated with an increased ratio of Bacteroidetes to Firmicutes and a greater abundance of beneficial microbial populations, including lactic acid bacteria, Bifidobacterium , and Akkermansia muciniphila (2, 91)

Conclusion: Pegozafermin treatment led to improvements in multiple biomarkers which correlated to histological endpoints

With the advancement of global industrialization, its incidence continues to rise, particularly in newly industrialized regions, which not only severely impairs patients' quality of life but also emerges as a major public health concern threatening digestive system health, accompanied by a substantial healthcare burden, thus necessitating the development of more effective and safer individualized treatment strategies

cremoris NZ9000 [66] indicating the clear role of this enzyme in oxidative stress protection mechanism in LAB

demonstrated that substituting hydrophobic amino acids with less lipophilic residues can reduce hemolytic activity without compromising antimicrobial activity (Vincenzi et al., 2024a)