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Astrocytes sense extracellular changes through receptors such as pattern recognition receptors and cytokine receptors, detecting pathogens, A aggregates or inflammatory mediators 4,41

Laboratory and field studies have consistently demonstrated that MT levels in fish increases with exposure to metals 22

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7 While extensive research has identified key aging markers and explored the individual mechanisms underlying these diseases, several critical gaps remain: (1) the shared and disease-specific regulatory networks governing aging across different pathologies are poorly characterized