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Although there is a broad clinical spectrum of glutathione synthetase deficiency, manifestations usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs (eg, respiratory distress, sepsis, hyperbilirubinemia) (62

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Accordingly, therapeutic strategies for PD might not only aim at lowering iron levels, but also consider regulating iron utilization, for instance by strictly controlling iron absorption