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The breakdown of calcium homeostasis affects the synthesis, release and reuptake of neurotransmitters, followed by excitotoxicity and loss of neurons ( Ferroptosis and cuproptosis are two specific modes of cell death that depend on the exposure to iron and copper, respectively (Zou et al., 2020

In addition to GPCRs, SCFAs are also inhibitors of intracellular HDACs, which attenuate the progression of renal fibrogenesis, ROS generation, and inflammation [144]

ALA is an antioxidant that is adept at preventing lipid peroxidation, which occurs in cellular membranes

Figure 1) (Song and Long, 2020)

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