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The oxidant-antioxidant imbalance in the erythrocytes of sALS patients was confirmed, more recently, in another study where GSH reductase and reduced GSH levels were also found to be significantly lower at 24 months from the onset of ALS, in patients who died shortly after [104]

However, modern lifestyles significantly reduce glutathione levels

It is also possible to hypothesise that an impaired gut epithelial barrier will impact the regulation of sodium and water absorption, which could also have an effect on BP

Regul Toxicol Pharmacol 27, 4760

A recent 2021 meta-analysis of 12 RCTs also supported the beneficial impacts on serum lipids, glucose, and CRP with the combination of CoQ 10 , red yeast extract, policosanols, berberine, folic acid, and astaxanthin [196]