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The importance of FBP for tumour cells is also underlined by the fact that fructose-1,6-bisphosphatase 1, a gluconeogenic FBP-degrading enzyme, is a tumour suppressor and depleted in clear cell renal cell carcinoma 73 , the most common form of kidney cancer, whereas nucleophosmin (NPM1) promotes pancreatic cancer progression by inhibiting fructose-1,6-bisphosphatase 1 74

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doi: 10.1590/2237-6089-2016-0077 11 YohnCNGerguesMMSamuelsBA

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