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Along the same lines, patients with recessively inherited GGT deficiency also had glutathionuria, which results from the absence of GGT activity on the apical surface of renal proximal tubules [9,19]

Although traditional treatment methods such as surgery, radiotherapy, and chemotherapy have increased the survival rate of patients, their efficacy remains unsatisfactory owing to the nonspecific distribution of drugs, high toxicity, and drug resistance of tumor tissues

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Physiol Rev (2015) 95:74984