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A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program

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Gastroenterology & Hepatology 12 (4), 231242

It is generally well-tolerated, though gastrointestinal side effects are common initially

Serious but less common risks may include: hypersensitivity reactions, hypokalemia (rare, with B12 correction of severe deficiency), and exacerbation of polycythemia