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3.5.1 Inhibition of bEV virulence activity and destruction of bEV integrity Therapeutic strategies that demonstrate the ability to impact the integrity of bEVs and/or hinder the functions of their virulence factors have shown promise

If these goals are not achieved within a certain time span, the ER stress triggers apoptosis, programmed cell death

Peroxiredoxin (PRX) was discovered in 1988 and is a novel peroxidase capable of reducing both hydroperoxides and peroxynitrate with the use of electrons provided by a physiological thiol like TRX (204, 205, 327)

(approximately 0.1%) ( 2 to generate significant amounts of O 2 -, the precursors to most ROS (Sohal, 1993)

Liu Z, Xiao M, Mo Y, Wang H, Han Y, Zhao X