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As new triacylglycerols accumulate, they reach a critical level when spontaneous condensation or nucleation by phase separation occurs, leading to an oil blister within the hydrophobic bilayer region, which attracts perilipins and other proteins that allow lipid droplets to grow further in patches of the membrane as lens-like swellings between the two membrane leaflets

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For instance, a zeolitic imidazolate framework (ZIF-8)-derived carbon dot system (ZCD) was engineered to carry doxorubicin and respond to the acidic tumor microenvironment through hierarchical size and charge transformations 183

The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer