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Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

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Transplantation studies demonstrate that BL treatment significantly reduces serum IFN- levels while promoting Treg expansion (Pareek et al., 2022), suggesting a dual mechanism that suppresses both neurotoxic microglial activation and effector T cell responses, while enhancing Treg-mediated protection of DA neurons