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[76] However, even though convincing experimental data have identified NF-B as a critical promoter of tumorigenesis, which creates a solid rationale for the development of antitumor therapy that is based upon suppression of NF-B activity, caution should be exercised when considering anti-NF-B activity as a broad therapeutic strategy in cancer treatment as data has also shown that NF-B activity enhances tumor cell sensitivity to apoptosis and senescence

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10.1159/000192953 46 PugazhenthiS.NesterovaA.SableC.HeidenreichK