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The second model is the Cys-sensor-independent mechanism, where KEAP1 function is hindered by proteinprotein interactions rather than being dependent on changes in Cys residues

Oxidative stress caused by pyocyanin impairs CFTR Cl transport in human bronchial epithelial cells

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Studies also reported that HIF-1 mediates the hypoxia-induced ferroptosis in normal cells in certain conditions, and HIF-2 mediates the inhibition effect of hypoxia on ferroptosis in some cancer cells

Impure peptides may contain bacterial endotoxins, residual solvents, or incorrect amino acid sequences, any of which could trigger unpredictable immune responses in someone whose immune system is already dysregulated