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(PMID 30969552) , with the approved product documented in the FDA Drugs@FDA database under the Vyleesi label

doi: 10.1089/ars.2008.2055

A.GonzlezA.RouparD.TeixeiraJ

Specifically, treatment with nicotinamide significantly reduced the levels of key pro-inflammatory cytokines, including TNF-, IL-1, and IL-6, alongside a marked suppression of TGF-1, a central mediator of fibrogenesis (Figure 4A) (Sani et al., 2025)