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Mechanisms include modulation of gonadotropin release, local growth factor activity, anti-inflammatory action, and stress-hormone reduction

In hepatocellular carcinoma, glutathione S-transferase Pi (GSTP) translocates to the nucleus and modulates redox signaling via the Nrf2-Keap1 complex

Agricultural biotechnology measures for improving spermidine content in crops - genetic and molecular engineering of polyamine metabolism At the molecular level, the most direct strategy to increase spermidine is to enhance flux through its biosynthetic pathway