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Marques et al., 2020), and it can also be explained by a CO 2 -related increase in H + ions concentration in the cellular environment, which is counterbalanced by acid-base compensation to normalize the intracellular pH

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1) Reveal the hypoxia mechanism of RA tissues and cells: Through single-cell sequencing, proteomics, and gene knockout technology, the interaction mechanism of HIF-1 on downstream signaling pathways and its temporal and spatial dynamic changes in the hypoxic microenvironment of RA was deeply explored, which provided a new perspective and new ideas for the development of new diagnostic biomarkers and the determination of new therapeutic targets

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Fresh stretch marks (the red or purple ones) usually fade with time into older white or silvery marks, but they rarely disappear completely