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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

When cells are under external stress, iPLA2 can hydrolyze oxidized PUFA-PLs to inhibit p53-induced ferroptosis

1i), a specific measurement of non-shivering thermogenesis

Additionally, exposure to toxins, heavy metals, and oxidative stress can disrupt enzymatic activity within the cycle, affecting its overall function and metabolic stability

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