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Stiffness or pain in the joints

Inversely, perturbation of mitochondrial dynamics produces profound and pleiotropic epigenomic consequences: conditional deletion of the fission factor Drp1 in oocytes causes peri- and post-implantation failure accompanied by transcriptional and proteomic dysregulation, disorganization of the subcortical maternal complex, and reduced DNA methylation and H3K27me3 levels [78]

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This allows cysteine oxidation data to be normalized to protein expression data to correct for changes in protein turnover (Parker et al., 2015)

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC