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The study found that m5C methylation modification-related genes were significantly correlated with the incidence of osteoarthritis and rheumatoid arthritis, regarded as a new potential diagnostic biomarker [109]

Consistently, by ChIP assay, we detected significant NRF2 binding in Nqo1 and Slc7a11 loci, along with induced association of H3K4Me4 and H3K9Ac after DMF treatment (Fig