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A landmark preclinical study published in Brain Research found that a single intranasal application of Semax (50 g/kg) produced a 1.4-fold increase in BDNF protein levels, a 1.6-fold increase in TrkB phosphorylation, and a 3-fold increase in BDNF mRNA expression in the rat hippocampus

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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program