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Hyperhomocysteinemia was related to vitamin B12 or folate deficiency in 55%, mutations in one or more genes of one-carbon or vitamin B12 metabolism in 11%, and severe renal failure in 15%

A library of nucleic acids encoding a plurality of modified antigen binding sites, wherein the modified antigen binding sites are derived from a first nucleic acid comprising a sequence encoding a first antigen binding site, made by a method comprising the following steps: (a) providing a first nucleic acid encoding a first antigen binding site

De Nicola AF, Garay LI, Meyer M et al (2018) Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects