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doi: 10.1159/000445293 153 Vicente-MuozSMorcilloIPuChades-CarrascoLPayVPellicerAPineda-LucenaA

Reduced connectivity in the prefrontal cortex and anterior cingulate gyrus and reduced neuroplasticity are found in depressive disorders and play important roles in the pathophysiology of depression (66)

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Similarly, the minimum abundance of Akkermansia or Bifidobacterium needed to exert antidepressant effects has not been defined, which limits the development of targeted microbiota interventions

Oosthuyse B, Moons L, Storkebaum E et al (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration