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Dysregulation of T-type channels has been implicated in several pathophysiological conditions, including pain, atrial fibrillation, epilepsy, hypertension, cancer, and congestive heart failure, although most of these disorders involve multiple contributing factors beyond T-type channel activity [68, 134]

A structure-based designed inhibitor of Bcr-Abl-T315I, ponatinib, was developed and used in the clinical trial

PMID: 58 SheteNCalabreseJTonettiDA

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