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Therefore, various approaches have been explored for drug delivery in the colon, with each relying on one or more of the following fundamental mechanisms: prodrugs, time-dependent formulations, pH-triggered polymeric systems, and microflora-activated drug release by biodegradable polymers (Teruel et al., 2020)

156 During the past decades, changes in dietary patterns and lifestyle modifications have had potential application in the treatment of AD and have received extensive attention in AD research, including calorie restriction, dietary approaches to stop hypertension, Mediterranean diet, and the KD

The obtained results demonstrated increased bladder preservation in cases with GLY administration in comparison with the CP group, although the effect was not as strong as in the case of Mesna + GLY administration

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