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This is a significant phenotype, as a similar reduction in circulating triglycerides was not observed with a liver-specific loss of critical lipogenic enzymes, such as fatty acid synthase (FASN) 81

Under normoxic conditions, p53 directly limits glucose uptake by repressing the transcription of GLUT1 and GLUT4, and induces TIGAR expression, thereby reducing PFK1 activity

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Given that the therapeutic effectiveness of type II PSs is highly dependent on the surrounding oxygen concentration, Wang et al

The nuclei were uniform with finely dispersed chromatin and clearly visible nucleoli (Fig