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Moreover, methotrexate is easily eliminated by kidney to cause a shortened plasma half-life and low bioavailability

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Talanta 43:17331738 Tan XP, Yang JD, Li Q, Yang Q (2015) Detection of glutathione with an off-on fluorescent biosensor based on N-acetyl-L-cysteine capped CdTe quantum dots

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In most cases this is fine, however some medications, in particular some hormones used in bioidentical hormone replacement therapy (BHRT), do not maintain their efficacy when they come into contact with digestive acids

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