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*Correspondence: Chen Chen, [email protected] Guo, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In addition, occasionally hyposthenuria and uremia occur (402, 403)

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But most factory-farmed animals are kept indoors and never even see soil during their lifetimes, so would certainly be deficient without supplementation

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