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Alternatively, Electroporation-Mediated Gene Therapy (EMGT) leverages PEFs to reversibly permeabilize membranes, enabling targeted delivery of genetic payloads (therapeutic genes/DNA constructs) for precision genome editing, cellular reprogramming, or molecular interventions ( Figure 1 )

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Due to likely combined linear and rotational injury, there are reported acute increases in -APP staining, indicative of tissue deformation and DAI (Leung et al., 2014)