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In conclusion, though two small human studies found no significant effect of selenium supplementation on the structure of the adult gut microbiota, most animal studies have shown that different forms of selenium supplements significantly regulate the structure of gut microbiota in animals

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Leung CM, de Haan P, Ronaldson-Bouchard K, Kim GA, Ko J, Rho HS, Chen Z, Habibovic P, Jeon NL, Takayama S, Shuler ML, Vunjak-Novakovic G, Frey O, Verpoorte E, Toh YC (2022) A guide to the organ-on-a-chip